Sirtuins Function as the Modulators in Aging-related Diseases in Common or Respectively
نویسندگان
چکیده
منابع مشابه
Sirtuins Function as the Modulators in Aging-related Diseases in Common or Respectively
IntroductIon According to the demographics, the world population over 60 years will double from 605 million to 2 billion people between 2000 and 2050. Aging is a complex process in which the organism and its ability to respond to external stresses become progressive decline. The degenerative aging process is the major underlying cause for aging‐related diseases, including hypertension, diabetes...
متن کاملSirtuins, aging and diseases
SIR2 and related genes (sirtuins) are NAD-dependent deacetylases that link metabolism, protein acetylation and aging in a variety of species. Sirtuins are also involved in the longevity conferred by dietary or calorie restriction (CR). The mammalian sirtuins SIRT1-7 are involved in changes in stress resistance and metabolism that are triggered by CR, which not only extends life span, but also p...
متن کاملSirtuins in Aging and Age-Related Disease
Sirtuins have been the focus of intense scrutiny since the discovery of Sir2 as a yeast longevity factor. Functioning as either deacetylases or ADP ribosylases, Sirtuins are regulated by the cofactor NAD and thus may serve as sensors of the metabolic state of the cell and organism. Here we examine the roles of Sirtuins in diverse eukaryotic species, with special emphasis on their links to aging...
متن کاملA therapeutic role for sirtuins in diseases of aging?
The sirtuins are a group of proteins linked to aging, metabolism and stress tolerance in several organisms. Among the many genes that have been shown to affect aging in model organisms, sirtuin genes are unique in that their activity level is positively correlated with lifespan (i.e. they are anti-aging genes). Sirtuins are a druggable class of enzymes (i.e. amenable to intervention by small mo...
متن کاملSirtuins as regulators of mammalian aging
the discovery that overexpression of yeast Sir2 deacetylase extends lifespan by as much as 30% over a decade ago [1], much effort has been invested in researching whether this effect is conserved in higher organisms as well. Indeed, in wormsand flies, two separate groups found that SIR2 extended lifespan as well, by 50% and 18%, respectively [1]. In parallel to the work in worms and flies, rese...
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ژورنال
عنوان ژورنال: Chinese Medical Journal
سال: 2015
ISSN: 0366-6999
DOI: 10.4103/0366-6999.158375